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Michiel was awarded a NWO grant with Martine Smit (VU) entitled "Viral GPCR-activated EV release as a novel therapeutic target in brain cancer".
Rubina officially promoted to PI at the Amsterdam UMC
Steven and Enzo were selected for oral presentations at NLSEV 2020 in Maastricht, next year ' NLSEV Rotterdam 2023!
Finally in a great team effort with the labs of Guillaume van Niel and Frederik Verweij we published our exosomes-biogenesis work in JCB using the increasingly popular EV-pHluorin reporter strategy.
ER membrane contact sites support endosomal small GTPase conversion for exosome secretion.
Projection of exosome release events (yellow spots) recorded by live TIRF microscopy in a cervical cancer cell (blue) over a time-course of 3 minutes. (Verweij et al JCB 2018). For this Frederik Verweij and Michiel designed a CD63-pHluorin construct that was recently awarded with the Addgene blue flame award as 100 samples have been distributed around the world! We also generated CD9 and CD81 versions that are available at Addgene. https://www.addgene.org/130901/
Steven en Enzo giving talks at NLSEV 2022 in Maastricht