Research focus Cancer cell signaling Molecular mechanisms of exosome biogenesis Inhibiting extracellular vesicle release as a therapeutic strategy in cancer
Curriculum Vitae Caitrín Crudden obtained her Masters degree in Cancer Research and Molecular Biomedicine at the University of Manchester (UK), after two research internships delving into the intricacies of cancer cell signaling. In 2014 she started a PhD at Karolinska Institutet (Stockholm, Sweden), developing novel approaches to control plasma membrane receptor (RTK/GPCR) expression and function in cancer, under the supervision of Dr. Leonard Girnita (Department of Oncology-Pathology). With a peaked interest in the central role of the endosome as a portal connecting extra- and intra-cellular signaling, following her PhD defense she joined the Exosome Research Group as a postdoctoral researcher. Here, she will explore the molecular mechanisms surrounding the endosome-to-exosome route, with particular focus on identifying therapeutic intervention opportunities. Her current project, funded by a KWF grant, aims to identify drugs to inhibit extracellular vesicle release to combat drug resistance in breast cancer.