Michiel Pegtel was recently invited to host the learning session “Exosomes-Biology, Mechanisms and applications” at the private office of mr Bill Gates, Seattle, Washington, USA.
Bill Gates, founder and prior CEO of Microsoft, heads the Bill and Melinda Gates foundation that aims to reduce inequities in health by developing new tools and strategies to reduce the burden of infectious diseases.
Together with 5 other KOLs in the field, Michiel gave a presentation on exosome dynamics and exosome-mediated miRNA transfer.
Caitrin Crudden has been awarded a Marie Curie individual fellowship on the project: "Molecular mechanism and inhibition of extracellular vesicle-mediated PD-L1 release in melanoma cells"!
Our new project on exosome-mediated delivery of CRISPR-Cas9 for cancer gene therapy has been selected for funding by VUmc CCA!
Our research supported by the Olympic open water swimming champion Maarten van der Weijden!
Projection of exosome release events (yellow spots) recorded by live TIRF microscopy in a cervical cancer cell (blue) over a time-course of 3 minutes.
“Exosomes-Biology, Mechanisms and applications” learning session. Bill and Melinda Gates foundation, Seattle, Washington, USA.
Exosomes, 40-100nm vesicles as shown by Electron Microscopy are presumably derived from endosomes. Exosomes are generally round but often appear as a 'cupshape' with EM revealing their double membrane structure.