Our new project "A quantitative and qualitative assessment of EV-miRNAs for signature discovery in liquid biopsies" has been funded!
Our new project "Liquid biopsy-based immune profiling for cancer patients’ personalized medicine" has been selected for funding by the AmsterdamUMC CCA foundation!
Review "Exosomes" by Michiel Pegtel and Stephen Gould published in Annual Review of Biochemistry!
Our new project on extracellular vesicle bound PD-L1 detection for patient stratification has been selected for funding by VUmc CCA!
Exosomes, 40-100nm vesicles as shown by Electron Microscopy are presumably derived from endosomes. Exosomes are generally round but often appear as a 'cupshape' with EM revealing their double membrane structure.
Projection of exosome release events (yellow spots) recorded by live TIRF microscopy in a cervical cancer cell (blue) over a time-course of 3 minutes.