Our new paper "Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling" has been published in The Journal of Cell Biology (Verweij et al, 2018).
Michiel Pegtel obtained a high risk KWF research grant to define whether inhibiting extracellular vesicle release from breast cancer cells prevents or reverses drug resistance
Rubina Baglio obtained a KWF research grant to study exosomes-driven alterations of mesenchymal stem cell immunomodulatory properties as novel therapeutic targets for osteosarcoma
Projection of exosome release events (yellow spots) recorded by live TIRF microscopy in a cervical cancer cell (blue) over a time-course of 3 minutes.
Welcome to our website. Here we briefly introduce the projects we are currently running. We work in multi-disciplinary teams on various topics with exosome biology as underlying focus. Our translational studies include the role of exosomes in mesenchymal stem cell biology, oncogenic herpesviruses, microRNAs, innate immunity, auto-immune disease and cancer metastasis. We use innovative mouse models, live-imaging techniques, deep-sequencing and proteomics to unravel the underpinnings of exosomes in health and disease and intend to translate this knowledge into clinical applications.
Exosomes, 40-100nm vesicles as shown by Electron Microscopy are presumably derived from endosomes. Exosomes are generally round but often appear as a 'cupshape' with EM revealing their double membrane structure.