Caitrin Crudden has been awarded a Marie Curie individual fellowship on the project: "Molecular mechanism and inhibition of extracellular vesicle-mediated PD-L1 release in melanoma cells"!
Our new project on exosome-mediated delivery of CRISPR-Cas9 for cancer gene therapy has been selected for funding by VUmc CCA!
Our research supported by the Olympic open water swimming champion Maarten van der Weijden!
Projection of exosome release events (yellow spots) recorded by live TIRF microscopy in a cervical cancer cell (blue) over a time-course of 3 minutes.
Welcome to our website. Here we briefly introduce the projects we are currently running. We work in multi-disciplinary teams on various topics with exosome biology as underlying focus. Our translational studies include the role of exosomes in mesenchymal stem cell biology, oncogenic herpesviruses, microRNAs, innate immunity, auto-immune disease and cancer metastasis. We use innovative mouse models, live-imaging techniques, deep-sequencing and proteomics to unravel the underpinnings of exosomes in health and disease and intend to translate this knowledge into clinical applications.
Exosomes, 40-100nm vesicles as shown by Electron Microscopy are presumably derived from endosomes. Exosomes are generally round but often appear as a 'cupshape' with EM revealing their double membrane structure.