Exosome-mediated communication in the tumor microenvironment
Regulatory RNAs in mesenchymal stem cell (MSC) differentiation and osteosarcoma
Therapeutic CRISPR-Cas9 delivery via exosomes
Curriculum Vitae Rubina obtained a first Master’s degree in Pharmaceutical Biotechnology and second one in Molecular and Cellular Biology at the University of Bologna (Italy). In 2007 she started a PhD in Medical Biotechnology at the Rizzoli Orthopaedic Institute, Bologna, to study the molecular control of osteogenic differentiation of mesenchymal stem cells (MSC) in physiological and pathological conditions. During her PhD, Rubina spent eight months at the Department of Gene Regulation of the Netherlands Cancer Institute, where she focused on the involvement of microRNAs in osteogenic differentiation and osteosarcoma development. In 2012 she obtained the FIRC (Italian Foundation for Cancer Research) postdoctoral fellowship to perform her research activity in the Exosomes Research Group. In 2013 Rubina obtained the L’Oréal-UNESCO award for Women in Science and in 2014 the FUV (Fondazione Umberto Veronesi) postdoctoral fellowship. In 2016 she obtained the Marie Skłodowska Curie grant to investigate the role of extracellular vesicle-mediated communication in osteosarcoma and bone-metastasizing tumors.
In 2017 Rubina obtained a KWF research grant from the Dutch Cancer Society to explore the Exosome-driven alterations of MSC immunomodulatory properties as novel therapeutic targets for bone cancers. In 2019 Rubina received a Vumc CCA grant on the rational design of CRISPR-Cas9 delivery via extracellular vesicle.