Welcome to our website! Here we briefly introduce the projects we are currently running. We work in multi-disciplinary teams on various topics with exosome biology as underlying focus. Our translational studies include the role of exosomes in cancer biology, metastasis, mesenchymal stem cell biology, oncogenic herpesviruses, microRNAs, innate immunity and auto-immune diseases. We use innovative mouse models, advanced live-imaging techniques, spectral flow cytometry, next generation sequencing and proteomics to unravel the underpinnings of exosomes in health and disease with the aim to translate this knowledge into clinical applications.
You can also find us on:
Amsterdam UMC group page: Group of Michiel Pegtel (amsterdamumc.org)
EV delta EV-delta – Website of the Netherlands Society for Extracellular Vesicles (nlsev.nl)
You can also find us on:
Amsterdam UMC group page: Group of Michiel Pegtel (amsterdamumc.org)
EV delta EV-delta – Website of the Netherlands Society for Extracellular Vesicles (nlsev.nl)
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Latest NEWS
16-09-2025 In our new paper we show that our in-house developed small RNA sequencing protocol is capable of detecting active Multiple Myeloma, monitoring treatment response and even predicts treatment outcome, all from 1 mL of plasma EVs! Circulating extracellular vesicle isomiR signatures predict therapy response in patients with multiple myeloma - ScienceDirect 28-06-2024 How do you develop an EV based liquid biopsy assay towards clinical implementation? Find out in our new paper: Towards IVDR-compliance by implementing quality control steps in a quantitative extracellular vesicle-miRNA liquid biopsy assay for response monitoring in patients with classic Hodgkin lymphoma 20-10-2023 We published our protocol IsoSeek for low input samples small-RNA sequencing in STAR protocols: https://doi.org/10.1016/j.xpro.2023.102645 05-07-2023 We published our tool NormSeq in Nucleic Acids Research: https://doi.org/10.1093/nar/gkad429 22-05-2023 We published our work in Reassesment of isomiR composition by small RNA seq in Cell Reports Methods: https://doi.org/10.1016/j.crmeth.2023.100480 15-12-2022 Michiel was awarded a NWO grant with Martine Smit (VU) entitled "Viral GPCR-activated EV release as a novel therapeutic target in brain cancer". |
29-04-2025 Bye Bye Steven! Our PhD Student is leaving the ERG and heading to the USA to continue his carreer.
26-04-2025 Exosomes Research Lab was represented again at ISEV!
26-02-2025 Goodbye party of Simone Foderado
26-11-2024 NLSEV2024 was in Utrecht this year. Cristina Gomez, Simone Foderaro, Hilal Nur Sensoy and Lotte Di Niro were presenting.
28-11-2024 We had 2 great days at the 7th retraite of the Cancer Center Amsterdam. More than 450 participants joined this meeting to share and talk about cancer research. Steven Wang and Hilal Nur Sensoy were able to give oral presentations. Amber Linders, Enzo Massaro, Simone Foderaro and Parisa Mapar shared their research with posters!
28-11-2023 2 impressive awards for our group at the NLSEV 2023 Meeting in Rotterdam!
Steven Wang and Hilal Nur Sensoy won the awards for best oral and best poster presentation respectively. The annual NLSEV meeting is where EV research from all of the Netherlands come together. 
1-12-2022 Rubina officially promoted to PI at the Amsterdam UMC
Projection of exosome release events (yellow spots) recorded by live TIRF microscopy in a cervical cancer cell (blue) over a time-course of 3 minutes. (Verweij et al JCB 2018). For this Frederik Verweij and Michiel designed a CD63-pHluorin construct that was recently awarded with the Addgene blue flame award as 100 samples have been distributed around the world! We also generated CD9 and CD81 versions that are available at Addgene. www.addgene.org/130901/
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